FIG. 2.
Functional connectivity changes between various states of consciousness. (A–G) Seven state comparisons from group paired t-test at p = 3.0 × 10−5 with panels showing decreased node functional connectivity with deepening of sedation (red lines, A–D) and increased connectivity in deep sedation (blue lines, E–G). The contrasts between wakefulness and deep sedation (C and F) were used to determine the collections of node pairs for computing DCI and ICI. Different dot colors distinguish major brain divisions, as indicated in Figure 1. (H) The number of connections at three different p-thresholds for the seven comparisons corresponding to panels (A–G). The trend of changes in the number of node pairs is similar at the three p-thresholds. DCI, decreased connectivity index; ICI, increased connectivity index.