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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2017 Oct;10(10):e005333. doi: 10.1161/CIRCEP.117.005333

Table 5.

Comparison between dofetilide reloading groups and previously published studies.

Studies Incidence of TdP (%) Comparison to
Same dose
reloading
P Value		 Comparison to
Higher dose
reloading
P Value
Dofetilide same-dose reloading 0/102 (0%) -- 0.050
Dofetilide higher-dose reloading 2/30 (6.7%) 0.050 --
Cleveland Clinic dofetilide initial loading6 17/1404 (1.2%) 0.62 0.058
DIAMOND-CHF3 25/762 (3.3%) 0.062 0.27
DIAMOND-MI4 7/749 (0.9%) 1.0 0.044
DIAMOND-AF7 4/249 (1.6%) 0.33 0.13
SAFIRE-D5 2/241 (0.8%) 1.0 0.062

P values are from Fisher's exact tests.