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. Author manuscript; available in PMC: 2017 Nov 14.
Published in final edited form as: Adv Funct Mater. 2017 Jul 6;27(32):1606632. doi: 10.1002/adfm.201606632

Figure 5.

Figure 5

(a) The Raman spectra of NT-NP (green) and MUC1-NP (red) showing distinct spectral signatures. The spectra of the injected NP cocktail (black) contain the major peaks from NT-NP (1210 cm−1) and MUC1-NPs (740 and 960 cm−1) (b) Photograph of a nude mouse with an MDA-MB-468 tumor xenograft in the left flank. (c) Bright field image of the excised tumor. (d) Ex vivo Raman image of the tumor (100% laser power, 1.5 s integration time, 5× objective). The predominantly red signal corresponds to the prevalence of MUC1-NPs throughout the tumor volume. Very few foci of NT-NPs accumulation represented by the green signal. (e) Hematoxylin and eosin (H&E) staining and (f) Immunohistochemical staining of MUC1 in the fixed tumor tissue demonstrated overexpression of MUC1 in the sectioned and imaged specimen.