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. Author manuscript; available in PMC: 2017 Nov 14.
Published in final edited form as: Adv Funct Mater. 2017 Jul 6;27(32):1606632. doi: 10.1002/adfm.201606632

Figure 7.

Figure 7

(a) Schematic representation of the blocked MUC1-NPs. The aptamer moiety is sterically shielded by 10 nm AuNPs. (b) TEM images of the blocked MUC1-NPs after 16 hours of serum incubation at 37 °C showing excellent structural integrity of the hybrid structures. (c) Bright field image of the excised tumors. (d) Ex vivo Raman image of the tumor (100% laser power, 1.5 s integration time, 5× objective). Both tumors exhibited very low uptake of the blocked NPs, suggesting that NP homing is due to the active targeting of the aptamers grafted on the MUC1-NPs.