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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Adv Chronic Kidney Dis. 2017 Sep;24(5):332–341. doi: 10.1053/j.ackd.2017.07.003

Figure 1. Renal function curves in normal individuals and CKD.

Figure 1

Panel A: relationship between NaCl excretion and body sodium chloride content (AS) above a basal value (A0). This analysis is based on Walser.69 The slope of the normal relationship (k, which is a time constant) is taken from Walser’s review of the literature. The slope appears to be reduced by CKD. Panel B: Classic renal function curve, as drawn by Guyton and colleagues.6 As argued by Guyton, CKD shifts the renal function curve downward and to the right, describing the increased salt-sensitivity in this population.