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. Author manuscript; available in PMC: 2018 Nov 15.
Published in final edited form as: J Immunol. 2017 Oct 16;199(10):3634–3643. doi: 10.4049/jimmunol.1700820

Fig. 4. LPS impairs insulin clearance and amplifies insulin receptor signaling.

Fig. 4

(A and B) Plasma TNF and IL-6 concentrations from mice 1 h after DBPS injection or challenge with LPS (400 μg/kg), insulin, or both. Data pooled from 2 experiments. (C - H) AKT and insulin receptor phosphorylation observed at 1 h by Western blot in mice challenged as in (A). Western blots are representative of 3 or more (liver and quadricep AKT, liver IR) or 2 (quad IR) independent experiments. Densitometry data are pooled from 3 or more (D, E, G) or 2 (H) experiments. (I) Plasma insulin and C-peptide concentrations at 1 h in mice challenged with insulin and C-peptide with or without LPS. Pooled data from 2 experiments. Error bars, mean ± SD. Statistically significant differences were determined by a 2-tailed unpaired t-test; * P ≤ 0.05.