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. Author manuscript; available in PMC: 2018 Apr 11.
Published in final edited form as: Nature. 2017 Oct 11;550(7675):244–248. doi: 10.1038/nature24265

Figure 3.

Figure 3

Assessment of tissue-sharing of XCI in a GTEx donor with highly skewed XCI. a) Distribution of the skewness of XCI in GTEx female samples (N=62, V3 release). Each data point shows the mean skew in XCI across tissue samples per individual. b) Classification of X-chromosomal genes (N=186) into full or incomplete and tissue-shared or heterogeneous XCI based on the analysis of ASE patterns across tissues. Error bars show the 95% credible interval. c-e) Examples of genes where the ASE-based assessment of XCI status match previously reported assignments (TSR2, inactive; XIST, escape; ZBED1, escape). Note that XIST is, unusually for an escape gene, expressed monoallelically, only from Xi. f) KAL1 shows strong evidence for tissue-specific escape. g-k) Genes without previous or conclusive evidence for escape from XCI but classified as incompletely inactivated in this sample. In c-k asterisks indicate that the Xi expression in the given tissue was significant at FDR < 1% (one-sided binomial test) and errors bars show the 95% confidence interval.