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. Author manuscript; available in PMC: 2018 Apr 11.
Published in final edited form as: Nature. 2017 Oct 11;550(7675):244–248. doi: 10.1038/nature24265

Figure 4.

Figure 4

Analysis of XCI using scRNA-seq. a) Proportion of genes demonstrating full and partial XCI in the ASE analysis in single cell RNA-seq data, and the concordance with previously reported XCI status. b-l) Examples of genes with different XCI patterns in scRNA-seq: previously reported inactive gene (b), known escape gene in PAR1 (c), escape gene with known exclusive expression from Xi (d) new candidates for escape genes that demonstrate incomplete XCI in only a subset of samples (e-k), and a known escape gene that shows escape of varying degrees in the three samples (Pearson's Chi-squared test for equal proportions, P=3.80×10-7) (l). Asterisk above a bar indicates that the proportion of Xi expression, i.e. blue bar, in a given sample is significantly greater than the expected baseline (FDR < 1%, one-sided binomial test). Error bars show the 95% confidence interval.