. Author manuscript; available in PMC: 2018 Apr 11.
Published in final edited form as: Nature. 2017 Oct 11;550(7675):244–248. doi: 10.1038/nature24265
Reprints and permissions information is available at www.nature.com/reprints
Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms