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. Author manuscript; available in PMC: 2018 Apr 11.
Published in final edited form as: Nature. 2017 Oct 11;550(7675):244–248. doi: 10.1038/nature24265

Figure 1.

Figure 1

Schematic overview of the study. Previous expression-based surveys of XCI1,2 have established the incomplete and variable nature of XCI, but these studies have been limited in the tissue types and samples assessed. To investigate the landscape of XCI across human tissues, we combined three approaches: 1) sex biases in expression using population-level GTEx data across 29 tissue types, 2) allelic expression in 16 tissue samples from a female GTEx donor with fully skewed XCI, and 3) validation using single cell RNA-seq by combining allelic expression and genotype phasing. WGS, whole genome sequencing; WES, whole exome sequencing; scRNA-seq, single-cell RNA-seq.