Figure 3.

Hypoxia‐sensitive vesicle loaded MN‐array patches for glucose‐responsive insulin delivery. (a) Schematic of the formation and release mechanism of GRV and the GRV‐containing MN‐array patch for in vivo insulin delivery triggered by a hyperglycemic state. (b) Photograph of the MN‐array patch. (Scale bar: 1 cm) (c) SEM image of MN‐arrays. (Scale bar: 200 μm) (d) BGLs in diabetic mice after treatment with blank MNs containing only cross‐linked HA, MNs loaded with human recombinant insulin, MNs loaded with GRV(E + I), MNs loaded with GRV(1/2E + I), or MNs loaded with GRV(I). Reproduced with permission from Ref. 54