Figure 3.

Compound 7.44 delays tumor growth of RUNX1/ETO cells in mice. A. Luciferase-expressing Kasumi-1 cells (2×10⁶ cells) were inoculated i.v. into irradiated (D=2Gy) NSG mice. Animals were treated i.p with compound 7.44 or 7.38 at 200–250 μg/Kg per animal per day, five days per week, beginning at week 8 post inoculation of Kasumi-1 cells. Tumor proliferation was monitored weekly by in vivo bioluminescence. One representative result is shown. B. Kaplan-Meier survival curve of recipient mice treated with compound 7.44 or 7.38. Data are summarized from two independent experiments. Log-rank test was used for statistical survival analyses.