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. 2016 Aug 17;1:16023. doi: 10.1038/npjgenmed.2016.23

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Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Graphical representation of network clusters formed by three core genes TP53, HSP90AA1 and ESR1 identified from 16 SNPs carrying antioxidant genes associated with IMI. These three genes control a larger network of 1835 genes connected by a total of 2179 edges (a). Structural alterations in any one of these genes could result in severe imbalances, taking into consideration the large number of genes they influence. Sets of genes under the control of three core genes (b) are highlighted as a projection from the central core network.