Table 2. Functional analysis showing genes associated with sperms' 20 genes are involved with EMT, xenobiotic metabolism, apoptosis estrogen response and KRAS signaling, which matches with the pathological phenotype of IMI.

	Gene set (sperm associated)	No. of genes	Genes	P-value
1	EPITHELIAL MESENCHYMAL TRANSITION	4	IGFBP2, IGFBP4, VEGFA, TGFB1	1.60E−06
2	UV RESPONSE UP	3	IGFBP2, IL6ST, GPX3	4.35E−05
3	XENOBIOTIC METABOLISM	3	IGFBP4, PLG, JUP	8.76E−05
4	HEDGEHOG SIGNALING	2	VEGFA, PLG	1.12E−04
5	IL6 JAK STAT3 SIGNALING	2	TGFB1, IL6ST	6.58E−04
6	APOPTOSIS	2	GPX3, TIMP2	2.22E−03
7	COMPLEMENT	2	PLG, TIMP2	3.40E−03
8	ESTROGEN RESPONSE EARLY	2	IGFBP4, IL6ST	3.40E−03
9	ESTROGEN RESPONSE LATE	2	IGFBP4, IL6ST	3.40E−03
10	KRAS SIGNALING DN	2	IGFBP2, SEPP1	3.40E−03