Table 3. Other risk variants identified in a cohort of 216 disease cases.
| Disease ID | C9orf72 expansion carriers | APOE E2/E2 genotype | APOE E2/E3 genotype | APOE E2/E4 genotype | APOE E3/E3 genotype | APOE E3/E4 genotype | APOE E4/E4 genotype |
|---|---|---|---|---|---|---|---|
| Total (n=216) | 3 (1.40%) | 0 (0.00%) | 26 (12.0%) | 1 (0.46%) | 131 (60.6%) | 45 (20.8%) | 13 (6.02%) |
| AD/MCI (n=40) | 0 (0.00%) | 0 (0.00%) | 1 (2.50%) | 0 (0.00%) | 17 (42.5%) | 15 (37.5%) | 7 (17.5%) |
| ALS (n=22) | 2 (9.09%) | 0 (0.00%) | 4 (18.2%) | 0 (0.00%) | 12 (54.5%) | 6 (27.3%) | 0 (0.00%) |
| FTD (n=21) | 1 (4.76%) | 0 (0.00%) | 1 (4.76%) | 0 (0.00%) | 13 (61.9%) | 5 (23.8%) | 2 (9.52%) |
| PD (n=56) | 0 (0.00%) | 0 (0.00%) | 10 (17.9%) | 1 (1.79%) | 39 (69.6%) | 5 (8.90%) | 1 (1.79%) |
| VCI (n=77) | 0 (0.00%) | 0 (0.00%) | 10 (13.0%) | 0 (0.00%) | 50 (64.9%) | 14 (18.2%) | 3 (3.90%) |
Abbreviations: AD/MCI, Alzheimer’s disease/mild cognitive impairment; ALS, amyotrophic lateral sclerosis; FTD, frontotemporal dementia; PD, Parkinson’s disease; VCI, vascular cognitive impairment.