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. 2016 Nov 30;1:16038. doi: 10.1038/npjgenmed.2016.38

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Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Differential expression of top-ranked genes within the discovery cohort. (a) Peripheral blood differential expression of the top 10 genes selected by GA/kNN in discovery cohort neurologically asymptomatic controls and AIS patients, with fold changes reported relative to control. Statistical significance of intergroup differences in gene expression was determined via two-sample two-way t-test, and P-values were corrected to account for multiple comparisons via Holm's Bonferroni method. (b) Coordinate pattern of peripheral blood expression across the top 10 genes plotted for individual subjects in both experimental groups. (c) Composite RNA expression levels of the top 10 genes generated via principal components analysis.