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. 2016 Mar 16;1:16004. doi: 10.1038/npjgenmed.2016.4

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Copyright © 2016 Center of Excellence in Genomic Medicine Research/Macmillan Publishers Limited

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Analysis of host-genome copy-number changes at HPV insertion sites. (a) CytoScan HD microarray (Affymetrix) and ChAS analysis (v 3.0) were performed from cervical tumour DNA to detect copy-number changes and structural alterations at sites of HPV insertion. Three 2J-COL cases are shown. The ChAS profile for each case indicates the HPV insertion breakpoints (dashed vertical lines), copy-number state (1), allele peak difference (2) smooth signal (3.) and density of probes (light/dark green bars). The chromosome locus and nearby genes are also shown. The Cytoscan data of the other 2J-COL samples are shown in Supplementary Figure S5. (b) Analysis performed as described in a, from three 2J-NL cases. The Cytoscan data of the other 2J-NLsamples are shown in Supplementary Figure S6. (c) Analysis performed as described in a, from three MJ-CL cases. (d) Analysis performed as described in a, from three MJ-SC cases.

Analysis of host-genome copy-number changes at HPV insertion sites. (a) CytoScan HD microarray (Affymetrix) and ChAS analysis (v 3.0) were performed from cervical tumour DNA to detect copy-number changes and structural alterations at sites of HPV insertion. Three 2J-COL cases are shown. The ChAS profile for each case indicates the HPV insertion breakpoints (dashed vertical lines), copy-number state (1), allele peak difference (2) smooth signal (3.) and density of probes (light/dark green bars). The chromosome locus and nearby genes are also shown. The Cytoscan data of the other 2J-COL samples are shown in Supplementary Figure S5. (b) Analysis performed as described in a, from three 2J-NL cases. The Cytoscan data of the other 2J-NLsamples are shown in Supplementary Figure S6. (c) Analysis performed as described in a, from three MJ-CL cases. (d) Analysis performed as described in a, from three MJ-SC cases.