Table 1. Existing AS genetic associations and new associations in previously associated loci.

Gene/locus	Cs	Posa	Current SNP	P-value	Risk/Prot	OR, 95% CI	RAF case/Con	Previously reported SNP	r2	Dʹ	Discovery Study
ERAP1	5	96,244,549	rs30187	3.0×10−34	T/C	1.3 (1.28–1.41)	0.40/0.34	rs31087	1.00	1.00	Burton et al.3
IL23R	1	67,702,526	rs11465804	1.3×10−25	T/G	1.9 (1.65–2.01)	0.96/0.93	rs11209026	0.89b	0.97b	Burton et al.3
IL23R	1	67,702,526	rs11465804	1.3×10−25	T/G	1.9 (1.65–2.01)	0.96/0.93	rs11209032	0.03	1.00	Evans et al.4
2p15	2	62,551,472	rs10865331	1.2×10−22	A/G	1.3 (1.20–1.32)	0.43/0.38	rs10865331	1.00	1.00	Reveille et al.5
21q22	21	40,465,534	rs2836878	1.1×10−16	G/A	1.3 (1.19–1.32)	0.77/0.73	rs2836878	1.00	1.00	Reveille et al.5
KIF21B-GPR25	1	200,877,562	rs7554511	3.8×10−16	C/A	1.2 (1.18–1.30)	0.75/0.71	rs2297909	0.89	0.96	Evans et al.4
GPR35	2	241,569,692	rs3749171	5.0×10−12	T/C	1.2 (1.15–1.29)	0.21/0.18	rs4676410	0.86	1.00	Cortes et al.11
IL6R	1	154,426,970	rs2228145	1.9×10−8	A/C	1.1 (1.09–1.20)	0.62/0.59	rs4129267	0.97	1.00	Cortes et al.11
ANTXR2	4	80,949,829	rs4333130	5.3×10−8	T/C	1.1 (1.09–1.20)	0.66/0.63	rs4333130	1.00	1.00	Evans et al.4
IL1R1	2	102,663,628	rs2310173	2.3×10−7	T/G	1.1 (1.08–1.18)	0.50/0.47	rs4851529	0.48	0.89	Cortes et al.11
IL1R1	2	102,663,628	rs2310173	2.3×10−7	T/G	1.1 (1.08–1.18)	0.50/0.47	rs2192752	0.02	0.23	Cortes et al.11
FCGR2A	1	161,479,745	rs1801274	4.9×10−6	A/G	1.1 (1.06–1.16)	0.50/0.47	rs1801274	1.00	1.00	Cortes et al.11
NOS2	17	26,096,597	rs2297518	2.7×10−6	A/G	1.1 (1.08–1.21)	0.21/0.19	rs2297518	1.00	1.00	Cortes et al.11

Abbreviations: AS, ankylosing spondylitis; CI, confidence interval; Cs, chromosome; OR, odds ratio; Prot, protective; Pos, position; RAF, risk allele frequency; SNP, single-nucleotide polymorphism.

Linkage disequilibrium calculated from 1000 Genomes data via the SNAP Browser from the Broad Institute.

^aHuman Genome Build 19.

^bCalculated from this data set.