Wednesday March 29, 2017
Registration Opens		2 pm
Satellite Symposium on HIV in the CNS Speakers TBA In collaboration with the City-Wide NeuroAIDS Group, aponsored by the Comprehensive NeuroAIDS Center (CNAC) at Temple University		2 – 5 pm
Trainee Poster Session Sponsored by the Early Career Investigator Committee		5 – 8 pm
1st Annual DISC Networking Hour Sponsored by the Diversity and Inclusion SNIP Committee Speaker: Dr. Ana Nuñez, M.D., Associate Dean for Diversity, Equity and Inclusion, Drexel University College of Medicine, PA, USA Diversity, Equity and Inclusion in Neuroimmune Pharmacology – A Mentoring Challenge		8 – 10 pm
ThursdayMarch 30, 2017
Breakfast		7 – 8 am
Presidents’ Welcome Dr. Michal Toborek, M.D., Ph. D., Leonard M. Miller Professor of Biochemistry and Molecular Biology, Vice-Chair for Research for the Department of Biochemistry and Molecular Biology, University of Miami, FL, USA		8 – 8:05 am
Presidential Symposium Dopamine Neurotransmission in HIV-1 Infection Chairs: Dr. Vishnudutt Purohit, Ph.D., NIDA, NIH, MD, USA Dr. Habibeh Khoshbouei, Pharm.D., Ph.D., University of Florida, FL, USA		8:05 – 9:50 am
Dr. Peter J. Gaskill, Ph.D., Drexel University College of Medicine, PA, USA Role of Dopamine Receptor Activation in HIV Entry
Dr. Franca Marino, Ph.D., University of Insubria, Varese, Italy Dopamine and immunity: from basic evidence to therapeutic opportunities
Dr. Jun Zhu, Ph.D., University of South Carolina, SC, USA Molecular mechanism of HIV-1 Tat interacting with human dopamine Transporter
Dr. Rosemarie Booze, Ph.D., University of South Carolina, SC, USA HIV-1 disrupts motivational processes via dopamine transporter dysregulation
Dr. T. Celeste Napier, Ph.D., Rush University, IL, USA Pathophysiology of the nucleus accumbens in HIV-1 transgenic rats is potentiated by cocaine self-administration
Dr. Jay McLaughlin, Ph.D., University of Florida, Gainesville, FL, USA Brain Exposure to HIV-1 Tat Protein Potentiates the Psychostimulant Effects of Morphine, Modulates Consumption and Reinstates Extinguished Reward-Seeking
Break		9:50 – 10:10 am
Presidential Lecture Introduction: Dr. Michal Toborek, M.D., Ph. D., University of Miami, FL, USA Dr. David Sulzer, Ph.D., Columbia University Medical Center, NY, USA Antigen display by dopamine neurons		10:10 – 11 am
Symposium 2 Novel mechanisms of CNS infection by emerging neurotropic viruses Chair: Dr. Eliseo A. Eugenin, Ph.D., Rutgers, USA Dr. Mark Challberg, Ph.D. NIAID, NIH, MD, USA		11 – 12:30 pm
Speakers: Dr. Mark Challberg, Ph.D., NIAID, NIH, MD, USA Introduction to Flaviviruses
Dr. Eliseo Eugenin, Ph.D., Rutgers University, NJ, USA Flaviviruses, a critical threat: Focus in CNS
Dr. Laura Yockey, Ph.D., Yale University, CT, USA Zika and CNS development
Ms. Courtney Veilleux, Rutgers University, NJ, USA Productive Zika infection in the human brain
Dr. Catherine Blish, Stanford University, CA, USA Zika virus infection induces cranial neural crest cells to produce cytokines at levels detrimental for neurogenesis
Meet the Mentors Luncheon Sponsored by the Early Career Investigator Committee		12:30 – 2 pm
Plenary Lecture Introduction: TBD		2 – 2:45 pm
Dr. Paul Kenney, Ph.D., Mount Sinai School of Medicine, NY, USA Immune signaling in the habenula and nicotine addiction
Symposium 3 Role of microbiome in health and disease: Implications in HIV disease progression and drug abuse Chair: Dr. Sabita Roy, Ph.D., University of Miami, FL, USA		2:45 – 4:15 pm
Dr. Shilpa Buch, Ph.D., University of Nebraska, NE, USA Opening statement
Dr. Dan Knights, Ph.D., University of Minnesota, MN, USA Plenary speaker, Title of talk: TBD
Dr. Jason Brenchley, Ph.D., NIAID, MD, USA Dysbiosis does not influence disease progression in SIV-infected Asian macaques
Dr. Charles Mactutus, Ph.D., University of South Carolina, SC, USA Integrity of the microbiome of the HIV-1 transgenic rat: Efficacy of the gut-brain-axis for treatment of neurocognitive impairment
Dr. Sabita Roy, Ph.D., University of Miami, FL, USA Title of talk: TBD
Dr.Santanu Banerjee,Ph.D., University of Miami, FL, USA Title of talk: TBD
Dr. Ivan Vujkovic-Cvijin, Ph.D., NIH, MD, USA Title of talk: TBD
Break		4:15 – 5 pm
Poster Session		5 – 8 pm
JNIP Editorial Board Meeting		7 – 9 pm
Friday	March 31, 2017
Breakfast		7 – 8 am
Local Symposium Neuroinflammatory Bases of Cognitive Impairment and Other CNS Disorders Chair: Dr. Olimpia Meucci, M.D., Ph.D., Drexel University, Philadelphia, PA, USA Dr. Dennis Kolson, M.D., Ph.D., Univ. of Pensylvania, Philadelphia, PA, USA		8 – 10:30 am
Dr. Norman Haughey, Ph. D., Johns Hopkins, MD, USA Neuroinflammation in Multiple Disease States
Dr. Paola Bezzi, Ph.D., University of Lausanne, Lausanne, Switzerland Neuroglia interactions and neurotransmission: new focus on monoaminergic pathways
Dr. Angelo Lepore, Ph.D., Thomas Jefferson University, Philadelphia, USA Neuroinflammatory mechanisms in axon regeneration and neuropathic pain following SCI: role of astrocyte communication with microglia and macrophages
15 minute break
Dr. Davide Ragozzino, Ph.D., University La Sapienza, Rome, Italy Synaptic pruning and microglia
Dr. Joan W. Berman, Ph.D., Albert Einstein College of Medicine, NY, USA CCL2-driven mchanisms of neuroinflammation & drug abuse
Dr. Robert Nagele, Ph.D., Rowan University, NJ, USA Autoantibodies as biomarkers in neurodegenerative diseases
1st Annual DISC Lecture Introduction: Dr. Kelly Jordan-Scuitto, Ph.D., University of Pennsylvania Dr. Astrid Cardona, Ph.D., University of Texas at San Antonio, TX, USA Absence of fractalkine/CX3CR1 induces perivascular clustering of microglia and fibrinogen leakage during systemic inflammation in mouse models of diabetic retinopathy		10:30 – 11:25 am
Symposium 5 Mechanisms of mitochondrial dysfunction associated with HIV-induced neurotoxicity Chairs: Dr. Adam Fields, University of California at San Diego, CA, USA Dr. Vasudev Rao, Ph.D., NIMH, MD, USA		11:30 – 12:30 pm
Dr. Josue Perez Santiago, Ph.D., University of California San Diego, CA, USA Mitochondrial Injury and Aging in HIV Infection
Dr. Avdoshina, V, M.D., Ph.D., Georgetown Univ. Med. Center, Washington, DC, USA Neurotoxic effect of Human Immunodeficiency Virus: cytoskeleton, mitochondria, and neuronal apoptosis
Dr. Todd Hulgan, M.D., M.P.H., Vanderbilt University, TN, USA Mitochondrial DNA variation and HIV-associated neurotoxicity
Dr. Kelly Stauch, Ph.D., University of Nebraska, Medical Center, Omaha, NE, USA Title: TBD
Lunch		12:30 – 2 pm
NIH Workshop on Grant Writing for Trainees (Boxed lunch provided)		12:30 – 2 pm
Participants Dr. Roger Sorenson, Ph.D., NIDA, NIH, MD USA Dr. Vishnudutt Purohit, Ph.D., NIDA, NIH, MD USA Dr. Rao Rapaka, Ph.D., NIDA, NIH, MD USA Dr. Changhai Cui, Ph.D., NIAAA, NIH, MD USA Dr. Jag Khalsa, Ph.D., NIDA, NIH, MD USA Dr. Jeymohan Joseph, Ph.D., NIMH, NIH, MD USA Dr. Vasudev Rao, Ph.D., NIMH, NIH, MD USA
Symposium 6 Alcohol and neuroimmune pharmacology Chairs: Dr. Abraham Bautista, Ph.D., Dir. OEA, NIAAA, NIH Dr. Santosh Kumar, Ph. D., Univ. of Tennessee Health Sci. Center, TN, USA		2 – 3:30 pm
Dr. Ilker K Sariyer, DVM, Ph.D., Assistant Professor, Department of Neuroscience and Center for Neurovirology, School of Medicine, Temple University, Philadelphia, PA Pre-mRNA missplicing of MCL-1 is involved in ethanol induced neurotoxicity
Dr. Dayne Mayfield, Ph.D., Professor, Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, TX Alcohol effects on microRNA, neuroimmune gene network, neuroinflammation
Dr. Marisa Roberto, Ph.D., Professor, The Neurobiology of Addictive Disorders, California Campus, The Scripps Research Institute, San Diego, CA Neuroimmune factors in alcohol-induced neuroadaptation in the central amygdala
Dr. Michael Lewis, Ph.D., Professor, Department of Psychology, Hunter College CUNY & Doctoral Program, CUNY Graduate Center Alcohol Neuropharmacology Alcohol neuropharmacology: Interaction with food intake and reward mechanisms
Dr. Hee-Yong Kim, Ph.D., Senior Investigator, Laboratory of Molecular Signaling, NIAAA, Bethesda, MD 20892 Docosahexaenoic acid in the nervous system: Modulation by ethanol
Dr. Narasimha Midde, Ph.D., Research Associate, Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN Role of cytochrome P450 in alcohol-mediated effects in brain cells: Strategy to target novel CYP pathway.
Break		3:30 – 4 pm
Workshop Exploration of Alternate Career Options for the Young Investigators in Neuroimmune Pharmacology Co-Chairs: Dr. Sanjay B. Maggirwar, Ph.D., University of Rochester, NY, USA Kathleen Borgmann, University of North Texas, TX, USA		4 – 5:30 pm
Sanjay B. Maggirwar, Ph.D., M.B.A., Need to Reform Biomedical Workforce Training
Additional speakers: TBD
Saturday	April 1, 2017
Breakfast		7:00 – 8:30 am
Symposium 7 Cannabinoids in the Immune System Chairs: Dr. Roger Sorenson, Ph. D., NIDA, NIH MD, USA Dr. Toby K. Eisenstein, Ph.D., Temple University, PA, USA		8:30 – 10 am
Dr. Pal Pacher, MD, Ph.D., NIAAA, NIH, MD, USA Advances in the Role of CB2 Activation in the Attenuation of Inflammation
Dr. Yuri Persidsky, M.D., Ph.D,. Temple University, PA, USA Cannabinoid type 2 receptor activation in neuroimmune modulation at blood brain barrier: Role in neuroprotection
Dr. Yumin Zhang, M.D., Ph.D., Uniformed Services University of Health Sciences, MD, USA Inhibition of the 2-AG hydrolytic enzyme ABHD6 in neuroinflammatory diseases
Dr. Toby K. Eisenstein, Ph.D., Temple University, PA, USA CB2 Agonists as Immunosuppressive Molecules: Mechanisms of Action
Break		10 – 10:25 am
Bill Narayan Lecture Introduction: Dr. Howard E. Gendelman, M.D., Margaret R. Larson Professor of Internal Medicine and Infectious Diseases, Chair, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA		10:25 – 11:30 am
Dr. Serena Spudich, M.D., Professor of Neurology; Division Chief, Neurological Infections & Global Neurology, Yale University, CT, USA Establishment of CNS HIV-1 reservoirs and brain injury: Is typical antiretroviral therapy too little, too late?
Early Career Investigator Symposium (Boxed lunch provided) Chairs: Dr. Marisela Agudelo, Ph.D., Florida International University, FL, USA Dr. Howard E. Gendelman, M.D., Univ. of Nebraska Med. Ctr, Omaha, NE, USA		11:30 – 2:30 pm
Speakers TBA – Selected ECITA Awardees, both pre- and post-doctoral, will give 5 minute presentations
Open Business Meeting		2:30 – 3:30 pm
Break		3:30 – 4 pm
Symposium 8 Computational and Systems Biology applied to the Brain Chair: Dr. Maria Cecilia Marcondes, Ph.D., The Scripps Research Institute, CA, USA		4 – 5:30 pm
Dr. Celia M. Schunter, Ph.D., King Abdullah University of Science and Technology, Thuwal, 23955-6900, SA The role of the brain in the adaptation to climate change
Dr. Chris Gaiteri, Ph.D., AD Center, Rush University, Chicago, IL, 60612, USA Neuroimaging the molecular state of the brain in cognitive decline and Alzheimer’s disease
Dr. Michelli Faria de Oliveira, Ph.D., University of California San Diego, CA, USA HIV compartmentalization in the CNS
Dr. Maria Cecilia G. Marcondes, Ph.D. The Scripps Research Institute, CA, USA Astrocyte-specific signatures in response to methamphetamine exposure in vitro
Banquet		7 – 10 pm
Hosted by the new SNIP president, Dr. Jonathan Geiger, Ph.D., Chester Fritz Distinguished Professor, School of Medicine and Health Sciences, University of North Dakota
Speaker: Dr. Paul McGonigle, Director, Division of Interdisciplinary and Career-Oriented Programs; Professor of Pharmacology & Physiology, Drexel University, College of Medicine, Philadelpia, PA, USA Academic Drug Discovery
Announcements, Awards and Adjournment of Conference
Meeting adjourned.