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. Author manuscript; available in PMC: 2018 Aug 14.
Published in final edited form as: ACS Biomater Sci Eng. 2017 Jun 9;3(8):1861–1868. doi: 10.1021/acsbiomaterials.7b00319

Figure 6. In vivo 3-week daily dose response.

Figure 6

Brown Norway rats (n=4) received a daily dose of brimonidine via saline eye drops or DNF for three weeks. IOP was recorded immediately prior to drug application. Values expressed are the difference between the experimental and contralateral eyes after normalizing individual eyes to baseline levels. The dash lines represent the mean IOP reduction values. DNF was able to sustain reduced IOP over the test period compared to saline eye drops (# indicates significantly different, P<0.001).