Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2018 Aug 14.

Published in final edited form as: ACS Biomater Sci Eng. 2017 Jun 9;3(8):1861–1868. doi: 10.1021/acsbiomaterials.7b00319

Brown Norway rats (n=3) received a DNF-FITC mat topically in the right eye (experimental eye) while the left eye received no treatment (contralateral eye). Animals were euthanized at 2 or 24 h and the ocular tissues harvested and immediately processed for cryosectioning. Fluorescent imaging of sections from various ocular organs showed most dendrimers were flushed from the cornea in 24 h. Over the same time period, FITC-G3.0-mPEG accumulated in the ciliary body of the experimental eye.

Brown Norway rats (n=3) received a DNF-FITC mat topically in the right eye (experimental eye) while the left eye received no treatment (contralateral eye). Animals were euthanized at 2 or 24 h and the ocular tissues harvested and immediately processed for cryosectioning. Fluorescent imaging of sections from various ocular organs showed most dendrimers were flushed from the cornea in 24 h. Over the same time period, FITC-G3.0-mPEG accumulated in the ciliary body of the experimental eye.