Table 3.
Incidence rates (95% CI) and hazard ratios (95% CI) of venous thromboembolism in relation to plasma galectin‐3 concentration, CHS, 1989‐2001
| Galectin‐3 Quintiles (ng/mL) | |||||||
|---|---|---|---|---|---|---|---|
| Q1 (3.1‐12.1) | Q2 (12.1‐14.5) | Q3 (14.5‐16.8) | Q4 (16.8‐20.2) | Q5 (20.2‐94.8) | P‐trend | Per 1‐SD increment in log galectin‐3 | |
| VTE, n | 22 | 31 | 25 | 21 | 25 | – | – |
| Person‐years | 7403 | 7074 | 7188 | 7009 | 6230 | – | – |
| Incidence ratea | 3.0 (2.0‐4.5) | 4.4 (3.1‐6.2) | 3.5 (2.4‐5.1) | 3.0 (2.0‐4.6) | 4.0 (2.7‐5.9) | – | – |
| Model 1 | 1 (Referent) | 1.49 (0.86‐2.57) | 1.13 (0.64‐2.02) | 1.02 (0.56‐1.86) | 1.39 (0.78‐2.48) | .60 | 1.03 (0.85‐1.24) |
| Model 2 | 1 (Referent) | 1.53 (0.88‐2.65) | 1.16 (0.65‐2.08) | 1.05 (0.57‐1.95) | 1.35 (0.74‐2.47) | .69 | 1.01 (0.84‐1.22) |
| Model 3 | 1 (Referent) | 1.46 (0.84‐2.56) | 1.07 (0.60‐1.93) | 0.92 (0.49‐1.72) | 1.05 (0.55‐2.01) | .63 | 0.92 (0.75‐1.13) |
| Model 4 | 1 (Referent) | 1.47 (0.84‐2.57) | 1.07 (0.59‐1.94) | 0.93 (0.50‐1.75) | 1.04 (0.53‐2.02) | .61 | 0.91 (0.74‐1.13) |
CHS, Cardiovascular Health Study; SD, standard deviation; VTE, venous thromboembolism.
SD log galectin‐3 = 0.34 log ng/mL.
Model 1: crude model.
Model 2: adjusted for age (continuous), sex (female, male), race (white, black), and center.
Model 3: Model 2 plus diabetes (yes, no), BMI (continuous), and eGFR (continuous).
Model 4: Model 3 plus log CRP (continuous), log Troponin T (continuous), and log NT‐proBNP (continuous).
a
Incidence rate is unadjusted and per 1000 person‐years.