Table 4.
Race‐specific incidence rates (95% CI) and hazard ratios (95% CI) of venous thromboembolism in relation to LGALS3 rs4644 genotype, ARIC, 1996‐2013
| rs4644 genotype | ||||
|---|---|---|---|---|
| Variable | AA | AC | CC | P‐trend |
| Whites | ||||
| N (%) | 1273 (17.0) | 3624 (48.4) | 2590 (34.6) | – |
| Mean (SD) Galectin‐3 (ng/mL) | 11.2 (2.7) | 14.0 (3.3) | 16.8 (4.3) | <.0001 |
| VTEs, n | 32 | 122 | 98 | – |
| Incidence ratea (95% CI) | 1.9 (1.4‐2.7) | 2.6 (2.2‐3.1) | 3.0 (2.4‐3.6) | – |
| Hazard ratios | 1 (Referent) | 1.34 (0.91‐1.98) | 1.52 (1.02‐2.26) | .04 |
| Blacks | ||||
| N (%) | 155 (7.7) | 804 (39.8) | 1063 (52.6) | – |
| Mean (SD) Galectin‐3 (ng/mL) | 12.2 (4.4) | 14.4 (4.1) | 17.6 (8.2) | <.0001 |
| VTEs, n | 8 | 46 | 63 | – |
| Incidence ratea (95% CI) | 4.0 (2.0‐8.0) | 4.6 (3.4‐6.1) | 4.7 (3.6‐6.0) | – |
| Hazard ratiosb | 1 (Referent) | 1.19 (0.56‐2.52) | 1.20 (0.57‐2.51) | .72 |
ARIC, Atherosclerosis Risk in Communities study; CI, confidence interval; VTE, venous thromboembolism.
a
Unadjusted incidence rates and per 1000 person‐years.
b
Adjusted for 10 principal components of ancestry.