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. Author manuscript; available in PMC: 2018 Nov 2.
Published in final edited form as: Cell. 2017 Oct 12;171(4):934–949.e15. doi: 10.1016/j.cell.2017.09.028

Figure 6. T Cells Expand in Proportion to Depletion of Neoantigens.

Figure 6

(A) Changes in T-cell population distribution (i.e., evenness) and changes in tumor mutation clonality by response.

(B) Relationship between the number of predicted neoantigens lost and the number of T-cell clones expanded on-therapy.

(C) Neoantigen ratios (mutations predicted to generate neoantigens per mutations not predicted to generate neoantigens) from mutations solely identified in pre-therapy samples compared with those identified solely in on-therapy samples. Data are presented as mean ± SEM.

(D) Graphical model depicting changes during anti-PD-1 therapy. (a) Changes in mutations and neoantigens during therapy. (b) Changes in TCR repertoire depend on exposure to prior immunotherapy. (c) Changes in immune landscape and checkpoints during therapy.