Table 1. EC50s for ISO and HAL for the WT-Cre and Δ-Cre virus-injected mice in the LORR and TC assays.
| Type of injection | Region injected | Behavioral test | EC50 ISO (SD) |
EC50 HAL (SD) | N (Gender) |
|---|---|---|---|---|---|
| AAV-WT-Cre-GFP | VN | LORR | 1.00 (0.09) | 0.90 (0.05) | 7 (4F/3M) |
| AAV-Δ-Cre-GFP | VN | LORR | 1.1 (0.1) | 1.02 (0.08) | 6 (4F/2M) |
| AAV-WT-Cre-GFP | VN | TC | 1.45 (0.09)* p = 0.002 |
1.35 (0.04)* p = 3.6X10-5 |
7 (4F/3M) |
| AAV-Δ-Cre-GFP | VN | TC | 1.2 (0.1) | 1.21 (0.02) | 6 (4F/2M) |
| AAV-WT-Cre-GFP | MPTA | LORR | 0.79 (0.06)* p = 0.01 |
0.82 (0.06) | 6 (3F/3M) |
| AAV-Δ-Cre-GFP | MPTA | LORR | 0.90 (0.07) | 0.87 (0.04) | 7 (3F/4M) |
| AAV-WT-Cre-GFP | MPTA | TC | 1.1(0.2) | 1.1 (0.1) | 6 (3F/3M) |
| AAV-Δ-Cre-GFP | MPTA | TC | 1.25 (0.05) | 1.23 (0.09) | 7 (3F/4M) |
| AAV-WT-Cre-GFP | CMT | LORR | 0.80 (0.07)* p = 0.003 |
0.77 (0.07)* p = 0.004 |
6 (4F/2M) |
| AAV-Δ-Cre-GFP | CMT | LORR | 1.0 (0.1) | 1.0 (0.1) | 6 (2F/4M) |
| AAV-WT-Cre-GFP | CMT | TC | 1.0 (0.1)* p = 0.008 |
1.02 (0.08)* p = 3.4X10-5 |
6 (4F/2M) |
| AAV-Δ-Cre-GFP | CMT | TC | 1.2 (0.1) | 1.31 (0.08) | 6 (2F/4M) |
| AAV-WT-Cre-GFP | DMT | LORR | 0.80 (0.03)* p = 0.001 |
0.74 (0.02)* p = 3.8X10-7 |
6 (4F/2M) |
| AAV-Δ-Cre-GFP | DMT | LORR | 0.93 (0.04) | 1.02 (0.05) | 6 (2F/4M) |
| AAV-WT-Cre-GFP | DMT | TC | 0.92 (0.09)* p = 0.0004 |
0.87 (0.04)* p = 1.2X10-7 |
6 (4F/2M) |
| AAV-Δ-Cre-GFP | DMT | TC | 1.2 (0.1) | 1.33 (0.07) | 6 (2F/4M) |
| AAV-WT-Cre-GFP | PAC | LORR | 0.71 (0.05)* p = 3.5X10-7 |
0.68 (0.06)* p = 0.0001 |
6 (1F/5M) |
| AAV-Δ-Cre-GFP | PAC | LORR | 0.95 (0.02) | 1.0 (0.1) | 6 (3F/3M) |
| AAV-WT-Cre-GFP | PAC | TC | 0.85 (0.05)* p = 9.4X10-8 |
0.77 (0.09)* p = 5.4X10-7 |
6 (1F/5M) |
| AAV-Δ-Cre-GFP | PAC | TC | 1.21 (0.06) | 1.23 (0.07) | 6 (3F/3M) |
* indicates p-values < 0.01. p values listed compare region specific KO EC50s to control animals injected with sham Cre.