Table 3. Methylation of studied genes in cord blood of offspring.
Gene | Infants conceived naturally,% (n = 30) |
Infants conceived through ICSI,% | ||
---|---|---|---|---|
Normal imprinting a (n = 6) |
Abnormal imprinting b (n = 7) |
Total (n = 13) |
||
H19 | 53.9 ± 2.9 | 55.5 ± 1.5 | 53.3 ± 1.2* | 54.3 ± 1.7 |
SNRPN | 42.5 ± 1.6 | 43.2 ± 1.2 | 42.5 ± 1.5 | 42.8 ± 1.4 |
KCNQ1OT1 | 39.0 ± 2.4 | 38.0 ± 2.1 | 38.0 ± 3.1 | 38.0 ± 2.6 |
a infants were given birth by patients with normal imprinting in sperm.
b infants were given birth by patients with abnormal imprinting in sperm.
*P< 0.05 in comparison to the normal imprinting group.