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. 2017 Nov 14;12(11):e0188090. doi: 10.1371/journal.pone.0188090

Fig 3. In silico gene expression analysis and KEGG pathway analysis.

Fig 3

(A) Low summed scores for miR-107 and miR-331-3p (miR sum score) tended to associate with poorer prognosis in the TCGA data set (n = 247) when dichotomized at the median. (B) Glioblastomas with unmethylated MGMT promoter (u-MGMT) had higher miR sum score than glioblastomas with methylated MGMT promoter (m-MGMT). (C) Stratified into groups based on MGMT methylation status and miR sum score, patients with low miR sum score and u-MGMT had the shortest survival. (D) KEGG pathway analysis based on predicted targets of hsa-miR-107, hsa-331-3p, hsa-548x and hsa-3125 in the Glioma Pathway performed using the DIANA-mirPath tool. Genes regulated by at least two miRNAs are indicated with red, genes regulated by one miRNA with yellow, and genes not regulated by any of the miRNAs with blue. (E) Possible mechanisms by which downregulation of the 4-miRNA signature contribute to shorter survival in patients with glioblastoma.