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. 2017 Oct 2;13(10):e1005662. doi: 10.1371/journal.pcbi.1005662

Fig 3. Network reconstruction at tissue level.

Fig 3

(A) Tumor development and drug resistance in the presence of tetraploid tumor cells following whole genome duplication (WGD). (B) Ploidy distribution in the 807 tumor samples and (C) genomic alterations: ploidy, mutations, normalized under-expression and over-expression changes from COSMIC database [34]. (D) Genomic alteration network obtained between average ploidy (violet), gene mutations (yellow, lower case) and under- or over-expressions (green, upper case). Graph predicted with miic R-package and visualized using cytoscape (blue edges correspond to repressions).