Table 1.
Descriptive Statistics Stratified By Cerebral Microbleed Location
| Characteristic | Comparison of Analyzed Sample to the Excluded Visit 5 Participants | Analyzed Sample Stratified by Cerebral Microbleed Location | |||
|---|---|---|---|---|---|
|
| |||||
| Excluded Sample (N=4,843) | Analyzed Sample (N=1,677) | No CMB (N=1,279) | Deep or Mixed CMB (N=136) | Strictly Lobar CMB (N=262) | |
|
| |||||
| Cognitive Status(N(%)) | |||||
|
| |||||
| Normal | 3671 (77) | 1072 (64) | 835 (65) | 82 (60) | 155 (59) |
| Mild Cognitive Impairment | 766 (16) | 605 (36) | 444 (35) | 54 (40) | 107 (41) |
| Dementia | 342 ( 7) | 0 ( 0) | 0 ( 0) | 0 ( 0) | 0 ( 0) |
|
| |||||
| Covariates | |||||
|
| |||||
| Female (N(%)) | 2829 (58) | 1006 (60) | 785 (61) | 81 (60) | 140 (53) |
|
| |||||
| Age in years (Mean(SD)) | 76 ( 5) | 76 ( 5) | 76 ( 5) | 77 ( 5) | 77 ( 5) |
|
| |||||
| Education (N(%)) | |||||
| Less than High School | 769 (16) | 218 (13) | 156 (12) | 20 (15) | 42 (16) |
| High School, GED, or Vocational School | 2009 (42) | 699 (42) | 531 (42) | 61 (45) | 107 (41) |
| Some College | 2054 (43) | 760 (45) | 592 (46) | 55 (40) | 113 (43) |
|
| |||||
| Race-site (N(%)) | |||||
| Forsyth County blacks | 103 ( 2) | 0 ( 0) | 0 ( 0) | 0 ( 0) | 0 ( 0) |
| Forsyth County whites | 946 (20) | 390 (23) | 288 (23) | 42 (31) | 60 (23) |
| Jackson blacks | 974 (20) | 441 (26) | 322 (25) | 38 (28) | 81 (31) |
| Jackson whites | 2 ( 0) | 0 ( 0) | 0 ( 0) | 0 ( 0) | 0 ( 0) |
| Minneapolis blacks | 10 ( 0) | 0 ( 0) | 0 ( 0) | 0 ( 0) | 0 ( 0) |
| Minneapolis whites | 1489 (31) | 404 (24) | 311 (24) | 27 (20) | 66 (25) |
| Washington County blacks | 16 ( 0) | 0 ( 0) | 0 ( 0) | 0 ( 0) | 0 ( 0) |
| Washington County whites | 1303 (27) | 442 (26) | 358 (28) | 29 (21) | 55 (21) |
|
| |||||
| Diabetes (N(%)) | 1349 (30) | 470 (28) | 353 (28) | 33 (24) | 84 (32) |
|
| |||||
| Hypertension (N(%)) | |||||
| Normal | 502 (11) | 186 (11) | 150 (12) | 12 ( 9) | 24 ( 9) |
| Prehypertensive | 684 (14) | 241 (14) | 184 (14) | 15 (11) | 42 (16) |
| Hypertensive | 3564 (75) | 1250 (75) | 945 (74) | 109 (80) | 196 (75) |
|
| |||||
| Current or Former Smoker (N(%)) | 2595 (61) | 945 (56) | 712 (56) | 82 (60) | 151 (58) |
|
| |||||
| Estimated Total Intracranial Volume in cm3 (Mean(SD)) | - | 1382 (156) | 1379 (157) | 1376 (147) | 1399 (157) |
|
| |||||
| Predictors of Interest | |||||
|
| |||||
| White Matter Hyperintensity Volume in cm3 (Mean(SD)) | - | 17 (17) | 15 (15) | 27 (23) | 20 (19) |
|
| |||||
| Total AD Signature Region Volume in cm3 (Mean(SD)) | - | 59 ( 7) | 60 ( 7) | 58 ( 7) | 59 ( 7) |
|
| |||||
| Total Gray Volume in cm3 (Mean(SD)) | - | 443 (45) | 444 (45) | 434 (45) | 442 (45) |
|
| |||||
| Frontal Volume in cm3 (Mean(SD))* | 151 (16) | 151 (16) | 148 (16) | 151 (16) | |
| Females | - | 144 (13) | 145 (13) | 141 (12) | 142 (12) |
| Males | - | 160 (15) | 161 (15) | 158 (15) | 161 (15) |
|
| |||||
| Number of Lacunar Infarcts (N(%)) | |||||
| 0 | - | 1390 (83) | 1085 (85) | 101 (74) | 204 (78) |
| 1 | - | 208 (12) | 143 (11) | 23 (17) | 42 (16) |
| 2 | - | 57 ( 3) | 37 ( 3) | 10 ( 7) | 10 ( 4) |
| ≥3 | - | 20 ( 1) | 12 ( 1) | 2 ( 1) | 6 ( 2) |
|
| |||||
| Number of Non-Lacunar Infarcts (N(%)) | |||||
| 0 | - | 1486 (89) | 1156 (91) | 113 (83) | 217 (83) |
| 1 | - | 147 ( 9) | 98 ( 8) | 16 (12) | 33 (13) |
| ≥2 | - | 42 ( 3) | 23 ( 2) | 7 ( 5) | 12 ( 5) |
|
| |||||
| Total Number of Infarcts (N(%)) | |||||
| 0 | - | 1261 (75) | 996 (78) | 88 (65) | 177 (68) |
| 1 | - | 272 (16) | 197 (15) | 27 (20) | 48 (18) |
| 2 | - | 89 ( 5) | 56 ( 4) | 12 ( 9) | 21 ( 8) |
| ≥3 | - | 53 ( 3) | 28 ( 2) | 9 ( 7) | 16 ( 6) |
|
| |||||
| Copies of the APOE ε4 Allele (N(%)) | |||||
| 0 | 3226 (71) | 1160 (72) | 897 (73) | 94 (71) | 169 (67) |
| 1 | 1245 (27) | 416 (26) | 314 (26) | 33 (25) | 69 (27) |
| 2 | 103 ( 2) | 38 ( 2) | 18 ( 1) | 6 ( 5) | 14 ( 6) |
NOTE: SD=Standard deviation. The statistics are the observed frequencies and means;
*
The frontal volume exhibited significant interactions with sex; thus sex-specific summary statistics are presented along with the overall (combined sex) values.