Table 1. Results of Cox regression analyses in rennes cohorts.

Variables	Univariate Cox model			Multivariate Cox model
	HR	95%CI	P value	HR	95%CI	P value
Rennes cohorts (n = 106)a
Patient age	1.026	1.005–1.049	0.016	1.031	1.007–1.056	0.011
KPS	1.000	0.986–1.013	0.942
Three-CpGs signature	0.354	0.209–0.601	< 0.001	0.381	0.220–0.662	0.001
MGMT methylation status	2.567	1.650–3.994	< 0.001	2.835	1.756–4.576	< 0.001
G-CIMP status	4.901	0.681–35.261	0.114
TCGA gene expression subtypesb	1.149	0.943–1.400	0.167
Gender	0.866	0.558–1.343	0.519
Extent of surgery (total/partial/biopsy)	0.642	0.437–0.944	0.024	0.549	0.358–0.841	0.006

HR = hazard ratio; CI = confidence interval; KPS = Karnofsky performance score; G-CIMP = gliomaCpG island methylator phenotype.

^aRennes cohorts included GSE22891 and Rennes cohort (n = 106).

^bTCGA gene expression subtypes includes mesenchymal, classical, proneural, and neural subtypes.

In bold type were reported statistically significant results.