Table 1. BMI1 reduces HU-induced S arrest in MCF7 cells.
CTRL | 0.1 mM | 0.3 mM | 0.5 mM | 0.8 mM | 1.0 mM | |
---|---|---|---|---|---|---|
EV BMI1 | EV BMI1 | EV BMI1 | EV BMI1 | EV BMI1 | EV BMI1 | |
G1 | 64.1 ± 1.8 65.3 ± 2.5 | 59.7± 0.1 58.7 ± 1.5 | 57.4 ± 4.2 58.9 ± 3.1 | 40.0 ± 2.2 52.9 ± 1.5* | 33.6 ± 2.9 51.4 ± 1.3* | 23.8 ± 1.1 45.1 ± 0.6* |
S | 15.8 ± 0.5 14.2 ± 1.3 | 24.5 ± 0.8 18.6 ± 0.4* | 31.0 ± 1.8 19.3 ± 0.9* | 51.6 ± 2.2 28.7 ± 0.6* | 59.7 ± 3.9 33.7 ± 2.2* | 68.8 ± 3.1 36.9 ± 0.1* |
G2/M | 20.1 ± 2.0 20.5 ± 1.9 | 15.8 ± 0.8 22.7 ± 1.2* | 11.6 ± 3.5 21.7 ± 2.2 | 11.4 ± 1.5 18.4 ± 1.1* | 6.7 ± 1.4 14.9 ± 0.9* | 7.4 ± 2.1 18.0 ± 0.5* |
Note: Cell cycle distributions were derived from three independent experiments and were presented as means ± S.E.; Ctrl: control; * p < 0.05 (in comparison to the respective cell cycle distributions of EV cells)