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. 2017 Sep 21;8(52):89761–89774. doi: 10.18632/oncotarget.21125

Figure 2. Axl-targeting inhibitor R428 inhibits the proliferation, migration and invasion of mouse tumor cells.

Figure 2

(A) ID8 cells were treated with vehicle or R428 at indicated doses before performing proliferation, migration and invasion assays. (B) ID8 cells were transfected with mock, control siNC or siRNA specific for Axl (siAxl-2) and subsequently subjected to proliferation, migration and invasion assays. Proliferation and invasion was plotted as a percentage of growth relative to vehicle-treated cells with migration plotted as a percentage relative to zero time point of each treated cells. The experiments were performed thrice with 3 technical replicates, and data are expressed as mean ± SEM, ns, not significant, *p < 0.05, **p < 0.01, ***p < 0.001, one-way ANOVA followed by Tukey's multiple comparisons test.