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. 2017 Sep 12;8(52):89887–89902. doi: 10.18632/oncotarget.20834

Figure 1. PAI-1 expression correlates with poor prognosis in patients with ovarian cancer.

Figure 1

Immunohistochemical staining of PAI-1 in different malignant ovarian tissue sections (A). Representative areas of three different ovarian cancers scored as 1, 2, and 3, and one normal ovarian tissue sample scored as 0. Sections from breast cancer are shown as positive control for PAI-1 staining, and as negative control stained with nonimmune sera. Bar, 100 μm. Kaplan-Meier plot showing progression-free survival (PFS) (B) and overall survival (OS) (C) of patients with ovarian cancer treated at Gifu University Hospital and Osaka University Hospital (n = 154) stratified by PAI-1 expression level. Kaplan-Meier plot showing PFS (D) and OS (E) of patients with serous adenocarcinoma (n = 54) stratified by PAI-1 expression level. Kaplan-Meier plot showing PFS of patients with ovarian cancer (n = 1307) (F) and PFS of patients with serous ovarian cancer (n = 1144) (G) stratified by PAI-1 gene expression. Patients are split by the threshold of lower tertile according to the microarray expression data for the probe representing SERPINE1 (202628_s_at). Kaplan-Meier plot showing PFS (H) (n = 395) and OS (I) (n = 485) of patients with stage II-IV high-grade serous ovarian cancer in TCGA database stratified by PAI-1 mRNA expression.