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. 2017 Oct 4;8(52):90132–90143. doi: 10.18632/oncotarget.21487

Figure 6. SESN2 and SESN3 suppresses NK-92 cell-mediated anti-ovarian cancer response in vivo.

Figure 6

(A) Representative dot plots showing the proportions of EpCAM-expressing OVCAR-3 cells in peritoneal cells. No tumor: no tumor inoculation. Tumor: peritoneal tumor inoculation. Len-S2+V: transfer of Len-S2-transduced NK-92 cells with peritoneal PBS injections. Len-S2+DOX: transfer of Len-S2-transduced NK-92 cells with peritoneal doxycycline injections. Len-S3+V: transfer of Len-S3-transduced NK-92 cells with peritoneal PBS injections. Len-S3+DOX: transfer of Len-S3-transduced NK-92 cells with peritoneal doxycycline injections. (B) Absolute number of EpCAM-expressing OVCAR-3 cells harvested from mouse peritoneal cavity. N=7 per group. (C to E) Activation of caspase-3 in EpCAM-expressing OVCAR-3 cells isolated from mouse peritoneal cavity. Representative Western blot images were shown in (C). Statistics for cleaved caspase-3 was shown in (D). Statistics for pro-caspase-3 expression was shown in (E). N=3 per group. *, p<0.05; ***, p<0.001.