Figure 4. Effects of LRRC8A or LRRC8D knockdowns on the swelling‐activated release of myo‐[³H]inositol.

Hypoosmotic medium‐activated myo‐[³H]inositol efflux was measured in cells transfected with negative control siRNA (siNC) or the gene‐specific siLRRC8A, siLRRC8D_1, or siLRRC8D_2. Data are the means ± SEM of 6–8 independent experiments per group performed in 2 astrocyte cultures. ^** P < 0.01, ^*** P < 0.001, maximal release values vs. negative control siRNA (siNC); ^# P < 0.05, ^## P < 0.01 integral 10‐min release values vs. siNC.