Figure 5. Effects of LRRC8C or LRRC8E knockdown on astrocytic swelling‐activated efflux of [³H]taurine (A) and d‐[¹⁴C]aspartate (B).

Cells were transfected with negative control siRNA (siNC), or the gene‐specific siLRRC8C or siLRRC8E. [³H]Taurine and d‐[¹⁴C]aspartate release rates were measured simultaneously in cells preloaded with both radiotracers. Data are the means ± SEM of 4–5 independent experiments per group performed in 3 different astrocyte cultures.