Table 2.

Uni- and multivariate analyses to identify predictors of overall survival or recurrence-free survival in hepatocellular carcinoma patients after potentially curative resection

Factor	Univariate				Multivariate
	OS		RFS		OS		RFS
	HR (95%CI)	P	HR (95%CI)	P	HR (95%CI)	P	HR (95%CI)	P
Sex (male)	1.487 (0.773-2.864)	0.235	1.354 (0.885-2.071)	0.163
Age (> 60 yr)	1.091 (0.627-1.772)	0.723	1.017 (0.723-1.430)	0.923
HBsAg (+)	1.275 (0.618-2.630)	0.511	1.365 (0.842-2.214)	0.207
Total bilirubin (μmol/L)	0.992 (0.964-1.021)	0.586	0.966 (0.979-1.013)	0.653
Prothrombin time (s)	1.071 (0.931-1.232)	0.340	1.064 (0.966-1.173)	0.210
Child-Pugh classification (B)	1.423 (0.523-3.875)	0.490	2.074 (1.098-3.915)	0.024
Hypersplenism (yes)	0.949 (0.477-1.887)	0.882	1.158 (0.738-1.817)	0.524
AFP (> 400 ng/mL)	2.063 (1.379-3.086)	0.000	1.321 (1.007-1.733)	0.044	1.738 (1.152-2.622)	0.008
HBV-DNA (> 1 × 104 IU/mL)	1.191 (0.798-1.777)	0.393	1.259 (0.962-1.649)	0.094			1.316 (1.002-1.729)	0.048
Tumor size (> 5 cm)	2.219 (1.456-3.382)	0.000	1.694 (1.291-2.223)	0.000	1.858 (1.213-2.848)	0.004	1.600 (1.216-2.105)	0.001
Nodule no. (multinodular)	1.425 (0.885-2.294)	0.145	1.370 (0.985-1.905)	0.061			1.427 (1.024-1.989)	0.036
Differentiation (grades 3-4)	1.396 (0.934-2.085)	0.103	1.347 (1.027-1.766)	0.031
Incomplete tumor capsule (yes)	2.366 (1.582-3.537)	0.000	1.664 (1.266-2.187)	0.000	1.998 (1.329-3.006)	0.001	1.468 (1.114-1.935)	0.006
MVI (yes)	3.412 (2.135-5.452)	0.000	2.180 (1.646-2.888)	0.000	2.524 (1.564-4.075)	0.000	1.959 (1.472-2.606)	0.000
Cirrhosis (yes)	0.922 (0.522-1.541)	0.757	1.359 (0.918-2.031)	0.125
Approach of resection (major )	1.576 (1.054-2.357)	0.027	1.177 (0.896-1.547)	0.242	1.611 (1.073-2.419)	0.021
Hepatic inflow occlusion (yes)	0.784 (0.519-1.185)	0.248	0.919 (0.649-1.217)	0.556

OS: Overall survival; RFS: Recurrence-free survival; AFP: Alpha-fetoprotein; MVI: Microvascular invasion.