Table 1.
Baseline characteristics of subjects:
| Subject 1 | Subject 2 | Subject 3 | |
|---|---|---|---|
| Age (years) | 58 | 72 | 24 |
| Sex | Female | Female | Male |
| Duration of symptoms (years) | 10 | 5 | 5 |
| Pre-treatment Phosphorous (2.5–4.5 mg/dl) | 1.8 | 1.5 | 0.7 |
| Calcium (2.15–2.55 mmol/l) | 2.37 | 2.54 | 2.20 |
| Creatinine (0.51–0.95 mg/dl) | 1.03 | 0.65 | 0.68 |
| 25-OH Vitamin D (> 30 ng/ml) | 54 | 53 | 18 |
| 1, 25 (OH)2 Vitamin D (18–64 pg/ml) | 32 | 26 | 16 |
| Intact FGF-23 (< 50 pg/ml) | 1382 | 131 | 509 |
| Pre-treatment TRP (%) | 15.6 | 19.4 | 14 |
| Pre-treatment Alkaline phosphatase (35–105 U/L) | 242 | 106 | 429 |
| PTH (15–65 pg/ml) | 518.2 | 71.8 | 82.5 |
| Octreotide SPECT/CT scan | Left proximal femur | Anterior cortex of left femur | Negative |
| FDG-PET/CT scan | Left proximal femur | Anterior cortex of left proximal femur prosthesis | Right ischium and acetabular uptake |
| DOTATATE-PET/CT scan | Not performed | Not performed | Right posterior inferior acetabulum |
| CT scan | Inconclusive1 | Proximal femur | Right posterior inferior acetabulum |
| MRI scan | Inconclusive1 | Proximal femur | 2.4 × 1.4 right ischium mass |
| Length of follow-up | 10 months | 7 months | 2 years 5 months |
1
Dedicated, CT and MRI were inconclusive due to artifact from metallic prosthesis, however, CT from both the Octreoscan SPECT/CT and FDG-PET/CT, when merged with isotopic imaging, could localize the lesion.