Table 2.
Incident First Fracture by Randomization Assignment
| DSE | ILI | Unadjusted | Adjusted for Age and Gender | Fully Adjusted Model | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Fracture Type | # of Events | Incidence Per 10,000 person-years | # of Events | Incidence Per 10,000 person-years | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value |
| All Fractures | 358 | 139 | 373 | 143 | 1.03 (0.89, 1.19) | 0.71 | 1.04 (0.90, 1.20) | 0.61 | 1.02 (0.88, 1.18) | 0.76 |
| Hand (Not Fingers) | 7 | 3 | 7 | 2 | 0.99 (0.35, 2.82) | 0.98 | 1.01 (0.35, 2.88) | 0.99 | 0.99 (0.35, 2.83) | 0.98 |
| Lower Arm or Wrist | 64 | 23 | 71 | 26 | 1.10 (0.78, 1.54) | 0.59 | 1.11 (0.79, 1.56) | 0.54 | 1.11 (0.79, 1.56) | 0.55 |
| Elbow | 14 | 5 | 17 | 6 | 1.20 (0.59, 2.44) | 0.61 | 1.20 (0.59, 2.44) | 0.61 | 1.23 (0.61, 2.51) | 0.56 |
| Upper Arm (Humerus), Shoulder, or Clavicle | 63 | 23 | 68 | 25 | 1.07 (0.76, 1.51) | 0.70 | 1.09 (0.77, 1.53) | 0.64 | 1.07 (0.75, 1.51) | 0.72 |
| Vertebra (Thoracic or Lumbar) | 26 | 9 | 28 | 10 | 1.06 (0.62, 1.81) | 0.82 | 1.07 (0.63, 1.83) | 0.80 | 1.08 (0.63, 1.86) | 0.77 |
| Tailbone | 3 | 1 | 4 | 1 | 1.31 (0.29, 5.87) | 0.72 | 1.35 (0.30, 6.01) | 0.70 | 1.27 (0.27, 5.92) | 0.76 |
| Pelvis | 4 | 1 | 14 | 5 | 3.47 (1.14, 10.54) | 0.03 | 3.53 (1.16, 10.74) | 0.03 | 3.43 (1.13, 10.42) | 0.03 |
| Hip | 17 | 6 | 29 | 10 | 1.69 (0.93, 3.07) | 0.09 | 1.78 (0.98, 3.25) | 0.06 | 1.63 (0.89, 3.00) | 0.12 |
| Upper Leg (Not Hip) | 5 | 2 | 6 | 2 | 1.18 (0.36, 3.87) | 0.78 | 1.18 (0.36, 3.85) | 0.79 | 1.20 (0.36, 3.94) | 0.77 |
| Knee (Patella) | 25 | 9 | 29 | 10 | 1.15 (0.67, 1.96) | 0.61 | 1.17 (0.68, 1.99) | 0.57 | 1.21 (0.71, 2.09) | 0.48 |
| Lower Leg or Ankle | 119 | 44 | 97 | 35 | 0.80 (0.61, 1.05) | 0.11 | 0.81 (0.62, 1.05) | 0.12 | 0.80 (0.61, 1.04) | 0.10 |
| Foot (Not Toes) | 23 | 8 | 26 | 9 | 1.12 (0.64, 1.96) | 0.69 | 1.11 (0.63, 1.94) | 0.72 | 1.10 (0.63, 1.94) | 0.73 |
| Frailty | 70 | 25 | 98 | 35 | 1.39 (1.02, 1.89) | 0.03 | 1.44 (1.06, 1.96) | 0.02 | 1.39 (1.02, 1.91) | 0.04 |
Frailty fracture is a composite of hip, pelvis, or upper arm/shoulder. Fully adjusted model includes the following variables: Age, Gender, Race, BMI, Smoking Status, Alcohol Consumption, Maximal MET value, Self-Reported Duration of Diabetes, Bone + Meds, Bone - Meds, Insulin Use from Any Source, Beck Depression Score, eGFR, HbA1c. Hazard ratio = HR. Confidence interval = CI.