TABLE 1.
Demographic, clinical, and echocardiographic data between preterm neonates with low versus high vasoactive inotropic score after patent ductus arteriosus ligation
| Data | VIS <20 (n = 91) | VIS ≥20 (n = 10) | P value |
|---|---|---|---|
| Age (d) | 28 (19, 49) | 24 (19, 35) | .43 |
| Male, n (%) | 39 (43%) | 4 (40%) | 1.00 |
| Weight (kg) | 1.1 (0.83, 1.62) | 0.88 (0.76, 3.10) | .52 |
| Height (cm) | 36 (32, 41) | 33.5 (29, 36) | .17 |
| BSA (m2) | 0.11 (0.09, 0.14) | 0.09 (0.07, 0.17) | .46 |
| Hospital LOS (d) | 78.5 (19, 126) | 103.5 (61, 130) | .41 |
| Postoperative LOS (d) | 56 (13, 99) | 75.5 (35, 119) | .33 |
| Gestational age (wk) | 25 (24, 27.5) | 25 (23.8, 27.5) | .80 |
| SBP (mm Hg) | 68 ± 15 | 58 ± 17 | .07 |
| DBP (mm Hg) | 33 (25, 42) | 36 (23, 39) | .85 |
| PDA:LPA | 0.7 (0.55, 0.98) | 0.82 (0.58, 0.99) | .62 |
| LS (%) | −18.0 (−23.0, −14.5) | −20.8 (−25.3, −15.2) | .52 |
| LSR (1/s) | −2.1 (−2.7, −1.5) | −2.1 (−2.8, −1.9) | .57 |
| CS (%) | −15.4 (−19.5, −11.8) | −17.4 (−18.8, −15.8) | .20 |
| CSR (1/s) | −1.8 (−2.2, −1.4) | −2.0 (−2.2, −1.7) | .32 |
| PDA gradient (mm Hg) | 20 (10, 33) | 18 (13, 34) | .73 |
| LVIDd (cm) | 1.7 (1.3, 2.0) | 1.3 (1.3, 1.7) | .09 |
| FS % | 0.41 (0.35, 0.44) | 0.39 (0.36, 0.49) | .95 |
| EDV (mL) | 4.3 (2.8, 6.6) | 2.7 (2.5, 4.6) | .11 |
| EF % | 0.60 ± 0.09 | 0.64 ± 0.05 | .20 |
| Ees (mm Hg/mL/m2) | 3.6 (2.7, 5.1) | 3.8 (2.9, 8.9) | .70 |
| Ea (mm Hg/mL/m2) | 2.5 (1.9, 3.2) | 2.3 (1.6, 4.2) | .76 |
| Ea:Ees | 0.69 ± 0.27 | 0.57 ± 0.13 | .03 |
| Creatinine change (mg/dL) | 0.0 (0.0, 0.1) | 0.3 (0.2, 0.3) | <.01 |
| Time to first extubation (d) | 12 (5, 26) | 6 (4, 41) | .85 |
| UOP first 24 h (mL/kg/h) | 3.7 (2.4, 5.7) | 1.3 (0.4, 4.2) | .10 |
Data reported as a mean ± standard deviation or median (interquartile range). VIS, Vasoactive inotropic score; BSA, body surface area; LOS, length of stay; SBP, systolic blood pressure; DBP, diastolic blood pressure; PDA, patent ductus arteriosus; LPA, left pulmonary artery; LS, longitudinal strain; LSR, longitudinal strain rate; CS, circumferential strain; CSR, circumferential strain rate; LVIDd, left ventricular internal diameter in diastole; FS, fractional shortening; EDV, end-diastolic volume; EF, ejection fraction; Ees, end-systolic elastance; Ea, arterial elastance; UOP, urine output.