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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: J Bone Miner Res. 2017 Jul 31;32(11):2219–2231. doi: 10.1002/jbmr.3202

Figure 4. Conditional epithelial inactivation of Isl1 leads to effects on proliferation in the liCL and laCL of mandibular mouse incisors.

Figure 4

(A-H) BrdU was injected for 90 min to label proliferating cells in the liCL and laCL (denoted by white, dashed lines). Magnified view of the liCL (A′,B′) showed an increase in the number of proliferating cells in mutants (B′) compared to controls (A′). The number of BrdU+ cells was quantified and confirmed to be increased in mutants (C) however, the length of the BrdU+ zone was unchanged. Conversely, in the laCL, the number of BrdU+ cells was quantified and shown to be decreased in mutants compared to controls (E,F,G). Furthermore, the length of the BrdU+ zone was significantly shortened in mutants (H). **, P<0.01.