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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: J Bone Miner Res. 2017 Jul 31;32(11):2219–2231. doi: 10.1002/jbmr.3202

Figure 8. Identification of differentially expressed genes between control and mutant mandibular incisors at E15.5 using RNA-Seq.

Figure 8

(A) RNA-Seq analysis revealed 357 differentially regulated genes with an FDR (false discovery rate) < 0.01. From this list, 131 genes were up-regulated 2-fold or higher (i.e., log2 FC (fold change)) and 139 genes were down-regulated 0.5-fold or lower. (B) Genes identified using RNA-Seq were confirmed to be differentially expressed between developing control (Co) and mutant (Mut) incisors using qPCR. Kif27a and Stfa1 expression levels were significantly higher in mutants compared to controls, whereas Otx2, Ptprv, Scg2, and Tekt2 were significantly lower in mutants. *, P<0.05; **, P<0.01).