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In vitro anti-malarial activity of diethyl 4-(4-(((3-aryl-1-phenyl-1H-pyrazol-4-yl)methyleneaminocarbamoyl)methoxy)phenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate (5a–5g)
| Compound | IC50 nM | IC90 nM | IC95 nM | IC99 nM |
|---|---|---|---|---|
| 5a | 16.87 | 7.98 | 8.64 | 9.14 |
| 5b | 8.66 | 3.81 | 5.60 | 7.88 |
| 5c | 8.08 | 3.98 | 4.36 | 4.64 |
| 5d | 4.40 | 1.22 | 1.8 | 2.31 |
| 5e | 10.49 | 4.72 | 6.21 | 7.87 |
| 5f | 9.94 | 3.98 | 4.29 | 4.53 |
| 5g | 9.94 | 3.85 | 5.37 | 7.58 |
| Chloroquine | 18.7 | – | – | – |
| Pyrimethamine | 11 | – | – | – |
| Artemisinin | 6 | – | – | – |
