Figure 2.

Efficacy of interferon-beta preparations and all immunomodulatory drugs on sustained disability progression decreases with age. Linear regression of the efficacy of all interferon-beta formulations against placebo on sustained disability progression as a function of age (top panel). Each contributing trial has assigned weight proportional to the number of subjects and trial duration (see Eq. 2 in Materials and Methods). The resulting linear regression was used to estimate percent inhibition of disability progression (%IDP) of interferon beta against placebo at baseline age (see Eq. 1). This estimate was then used to recalculate %IDP for all immunomodulatory drugs against placebo as a function of age (see Eq. 7). Linear regression of the efficacy of all drugs against placebo on sustained disability progression as a function of age (bottom panel). Again, each contributing trial has assigned weight proportional to the number of subjects and trial duration. The coefficient of determination (R²) and p-values are indicated in the respective plots, while the inset legends denote the trial indices.