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. 2017 Nov 14;7:15564. doi: 10.1038/s41598-017-15725-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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NTP treatment inhibited Th17 cell differentiation in vivo and in vitro. (a) Imiquimod induced Th17 cell differentiation in the mouse draining lymph node and NTP treatment inhibited Th17 cell differentiation. (b) Percentage of Th17 cells were represented as a graph. IMQ; Imiquimod, NTP: Non-thermal atmospheric plasma. LTP treatment inhibited (c) Th17 and (e) Th1 cell differentiation during in vitro differentiation. (d) Th17 cell percentage, and (f) Th1 cell percentage were represented as a graph from in vitro experiments. Three independent experiments were performed. *P < 0.05, **P < 0.005.