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. 2017 Nov 14;7:15578. doi: 10.1038/s41598-017-15790-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Quantified drug release in mice. (A) In vivo release kinetics curves with respect to irradiated light treatment time. (B) A representative white light structural image related to mouse 3 (M3), showing the Dox release in the tumor. (C) Quantified Dox fluorescence concentration map 1-minute post treatment light irradiation. (D) Quantified Dox fluorescence concentration map 10-minute post treatment light irradiation. The video, Exp 3.avi, shows the release kinetics, changes in released drug concentration with respect to treatment light irradiation for M3.