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. 2017 Nov 14;7:15578. doi: 10.1038/s41598-017-15790-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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System design and characterization. (A) Dual-modal, dual-channel endoscope that allows combined imaging and treatment scheme in a single platform. Structured light is projected onto tumor using the custom endoscope. Mouse flank shown highlighting the tumor and surrounding muscle. (B) Picture of compact and portable version of the instrument highlighting the separate components. (C) Overview of the system operating in two imaging modes (reflectance and fluorescence) to obtain corrected fluorescence maps for quantification of true Dox concentration. (D) Endoscopic image of fluorescent-positive United States Air Force (USAF) target. (E) Reflectance image of negative USAF target. Outlined region in (D) provides relative scale of the Fluorescence and Reflectance modalities.