Table 4.

The combined information for the 5 potential target genes/proteins that germacrone, curdione on breast cancer.

Genes ID	Other Name	Common name	Scores in BATMAN-TCM	KEGG Pathway	Entrez ID	GO Functions
ESR1	ER; ESR; ESRA; ESTRR; Era; NR3A1	estrogen receptor 1	80.882	Estrogen signaling pathway;Prolactin Signaling Pathway	2099	Involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
ESR2	ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2	estrogen receptor 2	22.373	Estrogen Signaling Pathway;Prolactin Signaling Pathway	2100	The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria.
SRC	ASV; SRC1; THC6; c-SRC; p60-Src	tyrosine-protein kinase Src	22.373	Estrogen Signaling Pathway;Prolactin Signaling Pathway;Oxytocin Signaling Pathway;	6714	May play a role in the regulation of embryonic development and cell growth.
TP53	BCC7; LFS1; P53; TRP53	tumor protein p53	22.373	P53 Signaling Pathway	7157	Mutations in this gene are associated with a variety of human cancers
VDR	NR1I1; PPP1R163	vitamin D (1,25- dihydroxyvitamin D3) receptor	22.373	Endocrine And Other Factor-Regulated Calcium Reabsorption;Mineral Absorption	7421	Principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer.