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. 2017 Nov 14;7:15560. doi: 10.1038/s41598-017-15505-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of MSC-EVs on DP cell proliferation and migration. (A) Histogram showing cell proliferation as determined by a CCK8 assay, 24 h after treatment with 0–100 µg MSC-EVs. The mean and SD of triplicate experiments are plotted. *p < 0.05, ***p < 0.001. (B) Fluorescent images of DP cells immunostained for PCNA 24 h after either no treatment or treatment with 20 or 40 µg MSC-EVs (scale bar, 20 μm). (C) Western blot analysis of Akt, ERK, Bcl-2 and GAPDH levels in DP cell lysates 24 h after either no treatment or treatment with 20 or 40 µg MSC-EVs. (D) Representative images of migrated cells (scale, 500 pixels) are shown, as well as a quantified bar diagram of migrated cells. The mean and SD of triplicate experiments are shown. **p < 0.01, ***p < 0.001. Student t-test was used.