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. 2017 Nov 14;7:15560. doi: 10.1038/s41598-017-15505-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MSC-EVs induce the anagen stage in C57BL/6 mice. (A) After shaving, the dorsal skin was treated with MSC-EVs (n = 6), PBS (negative control, n = 5), or 3% minoxidil (positive control, n = 6) every 2 d for 28 d. (B) The dorsal skin was photographed at 0, 4, 11, 15, 18, 21, 24, and 28 days. (C) Quantification of area of hair regrowth quantified by imageJ software, values are represented in percentage. Data are expressed as mean ± SD. ***p < 0.001. Student t-test was used.